Cheap Flights from Panama City to Santa Cruz starting at RM 565

We've found these cheap flights for you. You can book one-way or return flight tickets.

Round-trip
One way

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Cheapest time to fly from Panama City to Santa Cruz

We monitor flight fares to help you find the best deals effortlessly

Cheapest flights

From price

23 30
Apr

30 6
6 13
13 20
20 27
May

27 4
4 11
11 18
18 25
Jun

25 1
1 8
8 15

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

FAQ

When are flight tickets from Panama City (PTY) to Santa Cruz (SRZ) the cheapest?

Airlines adjust prices for flights from Panama City to Santa Cruz based on the date and time of your booking. By analyzing data from all airlines, on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
How much do flights from Panama City (PTY) to Santa Cruz (SRZ) cost?

According to Trip.com's data, the lowest price is around RM 2,021.
How long does it take to fly from Panama City (PTY) to Santa Cruz (SRZ)?

It takes about 4 hours 50 minutes to fly from Panama City (PTY) to Santa Cruz (SRZ).
What is the transportation method from the main airport to downtown in Santa Cruz?
- The distance from Viru Viru International Airport to downtown is about 17km, by taxi about 30 minutes.
What time does the latest flight from Panama City to Santa Cruz depart?

The latest flight departs from Panama City (PTY) at 21:56 and arrives in Santa Cruz (VVI) at 04:04.
What are the most popular airlines that fly from Panama City (PTY) to Santa Cruz (SRZ)?

Airlines with flights from Panama City (PTY) to Santa Cruz (SRZ): Boliviana De Aviación, Copa Airlines and United Airlines.
What's the most popular airline for non-stop flights from Panama City (PTY) to Santa Cruz (SRZ)?

Copa Airlines operates 1 direct flights from Panama City (PTY) to Santa Cruz (SRZ).
How many airports in Santa Cruz (SRZ)?

There are 1 airport(s) in Santa Cruz (SRZ): Viru Viru International Airport.

How to find a cheap flight from Panama City to Santa Cruz

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Panama City to Santa Cruz. Book your flights at the right time and save more.

Be flexible with your travel dates to get the cheapest flight from Panama City to Santa Cruz.

Simply tap "Date" on the flight search bar to browse through the calendar and check out airfare from Panama City to Santa Cruz over the next 6 months in 2025. If you're planning to fly within the next three months, it looks like the most affordable option is on Mon, Mar 31, with one-way flights priced at just RM 2898.

Compare cheap flight deals from Panama City to Santa Cruz across hundreds of airlines.

With our extensive search, you can compare prices from over 500 airlines to find the cheapest flight tickets from Panama City to Santa Cruz. The cheapest airline for this route is Copa Airlines.

Set up a Price Alert

By setting up a Price Alert for your journey from Panama City to Santa Cruz, you can easily keep an eye on ticket prices without having to check every day.

Don't miss out on cheap flight deals and promo codes from Panama City to Santa Cruz.

You can always find the latest offers through Trip.com Deals and Promo Codes for cheap flights. By signing up for a free membership, you'll get access to even more deals for your flights.

Book early or wait until the last minute.

It's usually best to book early. Flight tickets are often cheapest when they're first released, typically about a year before the departure date. So, have a look online as soon as the flights you're interested in become available. If you miss the cheapest time, you might still find some good deals as the departure date gets closer.

Search for flights on the go.

For the best travel flight booking experience, download the Trip.com app. You can search for cheap flights from Panama City to Santa Cruz and snag some exclusive deals just for you.

Flight Information from Panama City to Santa Cruz

Cheapest direct flight price	RM 564
Cheapest return ticket price	RM 1,721
Off-season for travel	March
Peak season for travel	May
Flight distance	3,476.98km
Average flight time	4 hours 50 minutes
Popular airline	avianca